[box]MTHFR is a gene that acts like a switch, turning various processes in the body either on or off. MTHFR or Methylenetetrahydrofolate Reductase takes folate and methylates it into methylfolate. This may not seem like a big deal, but it is one of the most important functions in the body. The link between MTHFR and Autism could be the most important development in Autism prevention and treatment.[/box]
Methylenetetrahydrofolate Reductase
Lately MTHFR has become a buzzword, tied closely with neurological disorders like Autism. The statistics cannot be ignored, 98% of children with Autism have an MTHFR genetic mutation which inhibits their ability to turn folate into methylfolate efficiently. Beyond this, between 40%-50% of Americans have some sort of MTHFR dysfunction, inhibiting the methylation cycle and causing a countless variety of health conditions.
Glutathione and MTHFR Gene Mutations
MTHFR makes you far more vulnerable to illness and infection, this is because it is tied directly to our Glutathione production.
People with MTHFR mutations almost always have low Glutathione levels, making them more susceptible to stress and oxidative stress while making them far less tolerant to toxins. This gets much worse with age, as the accumulation of toxins and cumulative damage of oxidative stress take their toll on the body. Speeding up the aging process and nurturing the development of a huge variety of diseases.
The methylation cycle is tied directly to our serotonin and dopamine levels, along with our homocysteine and Glutathione levels. When someone has a MTHFR mutation it handicaps the efficiency of the methylation cycle by up to 90%. Throwing our brain chemistry out of whack, leading to depression and cognitive impairment. Perhaps even more serious is the effects on our Glutathione and homocysteine levels.
Homocysteine is not converted into Cysteine (a key player in our Glutathione production). This means a dramatic increase in cellular damage and an even more dramatic decrease in our body’s master antioxidant Glutathione. Severely inhibiting our immune function and ability to fend off infection and disease.[typography font=”Cantarell” size=”10″ size_format=”px”]1[/typography]
MTHFR and Autism
So how does this extremely common genetic dysfunction tie in with Autism?
Beyond the staggering number of Autistic children with this mutation, one study examines the effects of certain Vitamins and Minerals on Autistic children and adults.
This study involved 141 children and adults with Autism. It was a double blind study that examined the biomarkers of the participants.
The results were remarkable, by improving the methylation cycle and Glutathione levels of the group, they noted significant improvements in behavior and receptivity, using the Parental Global Impressions-Revised rating scale.
Proving the efficacy of enhancing Glutathione and the methylation cycle in both children and adults with Autism. Supplementing with the proper vitamins and minerals proves to be a beneficial adjunct therapy for Autistic patients.
Treating MTHFR with Supplements
MTHFR affects the body’s ability to turn folate into methylfolate, therefore the most common treatment for MTHFR is supplementing with methylfolate. This helps balance the cycle and allow the body to increase its methylation efficiency.
Supplementing with Acetyl Glutathione is also a good idea for those with a MTHFR mutation, because they’re incapable of producing adequate levels of this vital antioxidant, it is extremely important to directly supplement levels. This does not fix the problem outright, but it certainly helps minimize damage to the body and prevent further illness.
Supplementing with both methylfolate and Acetyl Glutathione can help address the root cause of the methylation dysfunction as well as address the issues brought on through Glutathione deficiency.
MTHFR is one small gene, but it has proven to have a significant impact on many of our systems. With such a high number of people with a mutation of this gene it is important to study it further to help prevent a plethora of diseases and disorders brought on by poor methylation. For now, choosing a high quality supplement can help minimize symptoms and start repairing the damage caused by a poor methylation rate.
[button link=”https://glutathionepro.com/gsh-gold” size=”xl” color=”orange”]Glutathione Supplement Formulated for MTHFR[/button]
MTHFR Genetic Mutation Explained
I agree with the previous post. I believe I heard Dr. Neil Rawlins state 98% of those with autism have this genetic defect. I have searched, find many others on line repeating this, with no reference to the original source or study. If it is so, wouldn’t it be advantageous to replace folic acid in foods and vitamins with the special active form of methyl folate and hopefully observe changes in autism and the many other conditions said to be associated with this? Please help.
Hi, it is probably best not to supplement all foods, like the FDA has done by putting folic acid in wheat and bread products. Foods should only be supplemented as specialty items and not across the board.
This is because everyone with these mutations, methylates differently and there are three main outcomes with methyl folate supplementation: The first is a complete success with the supplementation and the person experiences consistent benefit; the second outcome is that the person does not see any difference at all; and the third outcome (which is what happened to me) is that the person feels amazing and like a new person for a week or so and then “crashes” and has negative experiences with it because of “over methylation”.
So if one, does indeed have an MTHFR mutation, it would be best to get treated by a healthcare professional who specializes in this mutation so they can monitor progress and modify dosage of methyl folate or any other supplements or meds that might prove to be helpful. The appropriate therapeutic dose for methyl folate can vary greatly for each individual depending on their particular individual methylation process; and it is important to get it right or a person could experience even more problems than they started with. Across the board supplementation of food with methyl folate could then cause as many problems as it might solve.
The study of genetic chemical molecular processing is so new and there is so much more to learn that it is best to be cautious and also read many comments on websites devoted to the subject to see if any patterns can be discerned among the many people who have written in with comments about their own journeys through treatment.
I too am trying to find the source of the 98%
Or we could just stop taking all the nutrients out of food in the first place, and then having to “replace” what we took out with SOME of the nutrients in artificial forms, quantities, and proportions.
We could stop putting glyphosate in food, pumping mercury into our children’s bodies, packing it into our teeth, and dumping fluoride into our water supplies. (I could go on, but I think you get the point.) Even those with decreased methylation capabilities didn’t seem to have such overwhelming difficulties in the decades before the world overwhelmed our bodies with boatloads of toxins that we simply can’t keep up with.
Only the boneheaded Western mainstream would respond to, “Look at what we screwed up with all our interference,” with “Hey, let’s fix it by interfering some more!”
http://www.jpands.org/vol9no4/boris.pdf
Thanks for posting this Kira.
If you read the second paragraph under the “Discussion” section (pg 107) it states: “Notably, only 2% of children with ASD in our study
presented without at least one polymorphism in the MTHFR gene.”
if only 2% of the children in the study did not have at least one polymorphism, then that suggests that 98% of the children in the study did. I believe that is where the 98% is coming from – or at least that is the only place that I am making the connection.
See my post below in response to Kira – I believe I located where they are coming up with the 98%
Autism isn’t a disease, thanks.